John Cusack as Martin Q. Blank

Minnie Driver as Debi Newberry

Dan Aykroyd as Grocer

Joan Cusack as Marcella

Alan Arkin as Dr. Oatman

Hank Azaria as Steven Lardner

Jeremy Piven as Paul Spericki

Mitchell Ryan as Mr. Bart Newberry

Michael Cudlitz as Bob Destepello

Steve Pink as Terry Rostand

K. Todd Freeman as Kenneth McCullers

Doug Dearth as Eckhart

Ann Cusack as Amy

Barbara Harris as Mary Blank

Jenna Elfman as Tanya

Belita Moreno as Mrs. Kinetta

Bill Cusack as Waiter

Patrick O'Neill as Nathaniel (as Pat O'Neill)

Benny Urquidez as Felix La PuBelle

David Barrett as Bicycle Messenger

Lance Gilbert as Assassin #2

Carlos Jacott as Ken

Bobby Bass as Assistant #1

Wendy Thorlakson as Melanie the Waitress