Julia Roberts as Isabel Kelly

Susan Sarandon as Jackie Harrison

Ed Harris as Luke Harrison

Jena Malone as Anna Harrison

Liam Aiken as Ben Harrison

Lynn Whitfield as Dr. P. Sweikert

Darrell Larson as Duncan Samuels

Mary Louise Wilson as Mrs. Franklin

Andre B. Blake as Cooper

Herbert Russell as Photo Assistant

Jack Eagle as Craft Service Man

Lu Sierra as Photo Shoot Model

Lauma Zemzare as Photo Shoot Model

Holly Schenck as Photo Shoot Model

Michelle Stone as Photo Shoot Model

Annett Esser as Photo Shoot Model

Monique Rodrique as Photo Shoot Model

Sal Mistretta as Ad Executive

Rex Hays as Ad Executive

Alice Liu as Ad Executive

Chuck Montgomery as Ad Executive

Mak Gilchrist as Rapunzel

Dylan Michaels as Prince

David Zayas as Policeman

José Ramón Rosario as Policeman

Lee Shepherd as Desk Sergeant

George Masters as Maitre D'

Anthony Grasso as Waiter

Robert F. Alvarado as Soccer Coach

Sebastian Rand as Tucker

Michelle Hurst as Nurse

Jason Maves as Brad Kovitsky

Julie Lancaster as Flight Attendant

Charlie Christman as Stone Fox

Amina Asep as Anna's Friend

Naama Kates as Anna's Friend

Jennifer Best as Anna's Friend

Robin Fusco as Anna's Friend

Jessica M. Osias as Anna's Friend

Electra Telesford as Anna's Friend

Michelle L. Brady as Anna's Friend

Zachary M. Hasak as Brad's Friend

Jordan Gochros as Brad's Friend

Rob London as Brad's Friend

James Ostrofsky as Brad's Friend

Chad Lavinio as Brad's Friend

John Sadowski as Brad's Friend

Matthew Doudounis as Brad's Friend

Andrea Dolloff as Cocktail Waitress

Eleanor Columbus as Girl in School Play (uncredited)

Mary DeBellis as Hostess (uncredited)

Tess Porter as Student in Thanksgiving Play (uncredited)

Nick Stellate as School Teacher (uncredited)

Gaël Zaks as The Soccer Coach (uncredited)