John Goodman as Pope Sergius II.

Johanna Wokalek as Johanna von Ingelheim

David Wenham as Gerold

Iain Glen as Village Priest

Edward Petherbridge as Aesculapius

Anatole Taubman as Anastasius

Lotte Flack as Johanna von Ingelheim - Age 10-14

Tigerlily Hutchinson as Johanna von Ingelheim - Age 6-9

Jördis Triebel as Joan's mother

Oliver Cotton as Arsenius

Nicholas Woodeson as Arighis

Suzanne Bertish as Bishop Arnaldo

Richard van Weyden as Eusthasius

Branko Tomović as Paschal

Lenn Kudrjawizki as Jordanes

Alexander Held as King Lothar

Christian Redl as Abbot of Fulda

Claudia Michelsen as Richilde

Katrin Pollitt as

Claudia Geisler-Bading as

Kristina Karst as Bona

Ian Gelder as Aio