Robin Williams as Bob Munro

Cheryl Hines as Jamie Munro

JoJo as Cassie Munro

Josh Hutcherson as Carl Munro

Jeff Daniels as Travis Gornicke

Kristin Chenoweth as Mary Jo Gornicke

Hunter Parrish as Earl Gornicke

Chloe Sonnenfeld as Moon Gornicke

Alex Ferris as Billy Gornicke

Will Arnett as Todd Mallory

Tony Hale as Frank

Brian Howe as Marty

Richard Ian Cox as Laird

Erika-Shaye Gair as Cassie (age 5)

Veronika Sztopa as Gretchen

Rob LaBelle as Larry Moiphine

Brian Markinson as Garry Moiphine

Kirsten Alter as Tammy

Brendan Fletcher as Howie

Matthew Gray Gubler as Joe Joe

Stephen E. Miller as Organ Stew Guy

Malcolm Scott as Kenny

Deborah DeMille as Dump Lady

Chad Krowchuk as Scruffy Teenager

Ty Olsson as Diablo Pass Officer

Bruce McFee as Independence Pass Officer

Rebecca Erwin Spencer as Waitress

Giacomo Baessato as Hip Hop Wannabe

Justin Chartier as Hip Hop Wannabe

Andrew Botz as Hip Hop Wannabe

Barry Sonnenfeld as Irv