Bob Hoskins as Mario Mario

John Leguizamo as Luigi Mario

Dennis Hopper as King Koopa

Samantha Mathis as Daisy

Fisher Stevens as Iggy

Richard Edson as Spike

Fiona Shaw as Lena

Dana Kaminski as Daniella

Mojo Nixon as Toad

Gianni Russo as Scapelli

Francesca P. Roberts as Bertha

Lance Henriksen as The King

Sylvia Harman as Old Lady

Desiree Marie Velez as Angelica

Andrea Powell as Brooklyn Girl

Heather Pendergast as Brooklyn Girl

Melanie Salvatore as Brooklyn Girl

John Fifer as Goomba Toad

Don Lake as Sgt. Simon

Terry Finn as Hatcheck Girl

Thomas Merdis as Goomba

Michael Harding as Goomba

Michael Lynch as Goomba

Scott Mactavish as Goomba

Wallace Merck as Goomba

Mona B. Fierro as Nun

Karen Brigman as Nun

Christi K. Work as Nun

Joy Reese as Nun

Lucy Alpaugh as Nun

Robert D. Raiford as T.V. Announcer

Harry S. Murphy as Reporter #1

Patt Noday as Reporter #2

Robert Lee Edwards as Scapelli Bodyguard

Ronald Lou Edwards as Scapelli Bodyguard

Matthew Zachary Hopkins as Pizza Delivery Boy

Robert Priester as Egon

Preston Lane as James

Jim Asaki as Japanese Businessman #1

Matt Nikko as Japanese Businessman #2

Kevin West as Devo Controller

Jeffrey Pillars as Devo Technician

Frank Welker as Creatures (voice)

Dan Castellaneta as Narrator (voice)

Fred Folger as Goomba (uncredited)

David Kraus as Singing Waiter (uncredited)

Ronnie Jay Leipold as Crazed Lunatic (uncredited)

Alan McCoy as Devo Technician (uncredited)

Mark Jeffrey Miller as Vendor (uncredited)

Carlene Moore as Prostitute (uncredited)

Neil Riddaway as Brooklyn Girl (uncredited)

Joe West as Archaeology Student (uncredited)