Bobby Cannavale as Max Bernal

William A. Fitzgerald as Ezra Bernal

Robert De Niro as Stan Bernal

Rose Byrne as Jenna

Vera Farmiga as Grace

Whoopi Goldberg as Jayne

Rainn Wilson as Nick

Tony Goldwyn as Bruce

Jackson Frazer as Ridgeway

Greer Barnes as Greer

Tess Goldwyn as Ms. Cathro

Ella Ayberk as Dr. Irina Tamarova

Lois Robbins as Susan

Alex Plank as Dr. Kaplan

Daphne Rubin-Vega as Agent Margo Jenkins

Matilda Lawler as Ruby

Joe Pacheco as Special Agent Costa

Amy Sheehan as Mrs. C.

Geoffrey Owens as Robert Segal

Barzin Akhavan as Dr. Jeffrey Wells

Donna Vivino as Noreen, Woman in Bar

Jacqueline Nwabueze as Sister Margaret

John Donovan Wilson as Sheriff Tom

Joshua Hinck as Tim

David Marciano as Detective Harrelson

Dov Davidoff as Self

Sophie Mulligan as Ariana

Thomas Duverné as Lance

Brian Donahue as Bouncer

Myra Lucretia Taylor as Margo

Jennifer Plotzke as Security Guard

Jack Parrish as Classmate

Josh Pesin as Diner

Louie Aronowitz as Drummer

Eddie A. Bryant as Bartender

Alex Barber as Ezra's Classmate

Oliver Morales as Ezra's Classmate

Julia Linger as Waitress

Skyler Wenger as Classroom Kid

Jimmy Kimmel as Jimmy Kimmel

Guillermo Rodriguez as Guillermo Rodriguez

Zoe Cali as Cally

Emma Willmann as Self

Mia Caro as Agent Pena

Bev Sheehan as Waitress at Diner

Megan Hennessy as Jackie