Keanu Reeves as Johnny Mnemonic

Dina Meyer as Jane

Takeshi Kitano as Takahashi

Ice-T as J-Bone

Dolph Lundgren as Street Preacher

Denis Akiyama as Shinji

Henry Rollins as Spider

Barbara Sukowa as Anna Kalmann

Udo Kier as Ralfi

Tracy Tweed as Pretty

Falconer Abraham as Yomamma

Don Francks as Hooky

Diego Chambers as Henson

Sherry Miller as Takahashi's Secretary

Arthur Eng as Viet

Von Flores as Viet

Victoria Tengelis as Pharmakom Receptionist

Warren Sulatycky as Yakuza Operator

Celina Wu as Mikiyo

Jamie Elman as Toad

Simon Sinn as Man in Hotel Lobby

Caitlin Carmody as Twin in Hotel Lobby

Erin Carmody as Twin in Hotel Lobby

Douglas O'Keeffe as Pharmakom Security Officer

Marlow Vella as Lotek Kid

Howard Szafer as Strike

Paul Brogren as Stump

Arthi Sambasivan as Nurse

Michael A. Miranda as Stick

Coyote Shivers as Buddy

Lynne Adams as Yakuza with Rocket Launcher

Michael Shearer as Yakuza Partner

Susan Tsagkaris as Opera Singer

Chris Comrie as Beijing Riot Newscaster

Gene Mack as Laslo

Robin Crosby as Girl in Hotel Room

Glenn Bang as Bandleader (uncredited)

Natalie Gray as Tall Chinese Man (uncredited)