Ellen Burstyn as Edna

Sam Shepard as Cal

Richard Farnsworth as Esco

Roberts Blossom as John Harper

Clifford David as George

Pamela Payton-Wright as Margaret

Jeffrey DeMunn as Joe

Eva Le Gallienne as Grandma Pearl

Lois Smith as Kathy

Madeleine Sherwood as Ruth

Richard Hamilton as Earl Carpenter

Carlin Glynn as Suzy Kroll

Lane Smith as Don

Penelope Allen as Ellie

Ebbe Roe Smith as Hank Peterson

John Tillinger as Dr. Herron

Trazana Beverley as Dr. Ellen Baxter

Ralph Roberts as Buck

George Sperdakos as Dr. Hankins

Bernard Behrens as Dr. Fisher

James Blendick as 1st Scientist

Vernon Weddle as 2nd Scientist

David Calkins as Man in Bar

Harvey Christiansen as Ned

Therese East as Ada Carpenter

Lou Fant as Harvey

Jessie Lee Fulton as Becky

David Haney as Jack Coldren

Claudette Harrell as Woman in Dance Hall

James N. Harrell as Doc Lurkin

Jennifer McAllister as Joanie

Don Michaelson as Doctor

A.G. Mills as Uncle Ely

Zeke Mills as Uncle Ely

Edith Mills as Aunt Carrie

Eva Mokry as Daisy Coldren

Edward Pflaum as Gay Keener

Elfrieda Russell as Zee

Shane Sinutko as Skateboard Boy

Tommy Splittgerber as Man in Dance Hall

Douglas G. Jacobson as Man in Dance Hall

Joshua Dean Stewart as Bobby

Ruth N. Straw as Avarilla

Tom Taylor as Clyde

Brett Lamar Turner as Lester Coldren

Sylvia Walden as Louise

Carol Williard as Nurse

Tracy E. Wilson as Lizzie Coldren

William D. Wittliff as Man in Bar

William Ellis Smith as Man in Truck

Sally Bondi as Sarah (uncredited)

Greg Scholl as Boy with Harmonica (uncredited)

Dan'l Terry as Polio Survivor at Church (uncredited)