Josh Lucas as Don Haskins

Derek Luke as Bobby Joe Hill

Jon Voight as Adolph Rupp

Austin Nichols as Jerry Armstrong

Evan Jones as Moe Iba

Mehcad Brooks as Harry Flournoy

Damaine Radcliff as Willie 'Scoops' Cager

Alphonso McAuley as Orsten Artis

Emily Deschanel as Mary Haskins

Red West as Ross Moore

Al Shearer as Nevil Shed

Kip Weeks as Togo Railey

Wilbur Fitzgerald as Wade Richardson

Andy Stahl as Dr. Ray

Brett Rice as George McCarty

Mitch Eakins as Dick Myers

Sam Jones as Willie Worsley

Wallace Merck as Racist - Cole Field House

Pat Hazell as Kentucky Booster

Wayne Ferrara as Iowa Reporter

Tatyana Ali as Tina

John Drap as Awards Host

Afemo Omilami as Mr. Flournoy

Mike Franklin as Student (uncredited)