Samuel L. Jackson as Lorenzo Council

Julianne Moore as Brenda Martin

Edie Falco as Karen Collucci

Aunjanue Ellis-Taylor as Felicia

William Forsythe as Boyle

Anthony Mackie as Billy Williams

Peter Friedman as Lt. Gold

Domenick Lombardozzi as Leo Sullivan

Aasif Mandvi as Dr. Anil Chatterjee

Philip Bosco as Priest

Clarke Peters as Reverend Longway

LaTanya Richardson Jackson as Marie

Portia as Doreen / Rafik's Sister

Fly Williams III as Rafik

Haneefah Wood as Vicky / Rafik's Sister

Donna Cutugno as Elaine

Genevieve Hudson-Price as Tina

Joe Forbrich as Hal

Ron Eldard as Danny Martin

Dorian Missick as Jason Council

Chance Kelly as Visored Cop at Riot

Colman Domingo as Male Patient

Garett Knights as Gannon Resident (uncredited)