Jim Carrey as Lloyd Christmas

Jeff Daniels as Harry Dunne

Laurie Holden as Adele

Rachel Melvin as Penny

Kathleen Turner as Fraida

Rob Riggle as Travis / Captain Lippincott

Tembi Locke as Dr. Walcott

Paul Blackthorne as Emergency Room Doctor

Brady Bluhm as Billy

Patricia French as Ms. Sourpuss

Steve Tom as Dr. Pinchelow

Don Lake as Dr. Meldman

Eddie Shin as Gordy

Atkins Estimond as Gus

Tommy Snider as Tom

Lindsay Ayliffe as Professor Garabedian

Matthew Cardarople as Inventor No. 1

Bill Murray as Ice Pick

Grant James as Mr. Stainer

Taylor St. Clair as Mrs. Steiner

Erin Allin O'Reilly as Asylum Nurse No. 1

Walt Arnett as KEN Audience Member

Erika Bierman as Fanny at Age 13

Kassidy Claire as Fanny at Age 5

Carly Craig as Young Fraida

Bryan Dilbeck as Dr. Dilbeck

Dalton E. Gray as Young Harry

Michael McCrudden as Audience Member

June Shannon as Harry's Trailer Park Wife

Maia Moss-Fife as Receptionist

Jeff Sumner as Convention Official

Julius Sharpe as KEN Conference Attendee

Dave Walpole as KEN Conference Attendee

Elizabeth Cooper as Mrs. Julie James

Michael Yama as Harry's Dad

Nancy Byers Farrelly as Asylum Nurse #2

Derek Holland as Asylum Patient

Brendan Boyle as Asylum Patient

Swizz Beatz as Ninja Leader

Mike Cerrone as Trucker

Sean Gildea as Trucker's Pal

Brett Wyman as Inventor #2

Jo Helton as Mrs. Snergle

Edward Barbanell as Nursing Home Orderly

Mariann Neary as Farmer's Wife

John Imlay as Farmer

Jon Barinholtz as Inventor No. 3

Lucas Daniels as Bartender

Carter Hicks as Bus Kid

Baxter Cooper Rogers as Prom Date

Sandra Dorsey as Stuffy Woman

Arielle Liberman as Emergency Room Nurse

Jon Barry as Emergency Room Orderly

Jesse Gines as Emergency Room Orderly

Robin O'Neal Sorensen as Emergency Medical Technician #1

Chris Randall Sorensen as Emergency Medical Technician #2

Daniel Greene as Wheelchair Ninja

Will Coogan as Room Service Waiter

Caryle Seim as Trailer Grandma

Danny Murphy as Joystick Victim

Paul Bednarz as KEN Convention Employee (uncredited)

Jennifer Cocker as Young Inventor (uncredited)

John Deifer as Mental Patient (uncredited)

Gregory Fears as Man at Gas Station (uncredited)

Abigail Gamache as Prom Attendee (uncredited)

William Goodrum as Prom Singer (uncredited)

Walter Hendrix III as Street Patron (uncredited)

Angela Kerecz as Waitress (uncredited)

John Merical as Neighbor (uncredited)

Rhomeyn Johnson as Bus Driver

Nancy Yee as Harry's Mom