Michael Jai White as Al Simmons / Spawn

Martin Sheen as Jason Wynn

John Leguizamo as Clown / Violator

Theresa Randle as Wanda Blake

Nicol Williamson as Cogliostro

D. B. Sweeney as Terry Fitzgerald

Melinda Clarke as Jessica Priest

Miko Hughes as Zack

Sydni Beaudoin as Cyan

Michael Papajohn as Glen, Zack's Dad

Frank Welker as The Devil Malebolgia (voice)

Tony Haney as African Liaison

Todd McFarlane as Bum

Simon Rhee as Hong Kong Military Air Base Person (uncredited)

Robia LaMorte as XNN Reporter

John Cothran as African Liaison

Caroline Gibson as News Anchor

Marc Robinson as Punk #1

Chris Coppola as Punk #2

Jay Caputo as Punk #3

Darryl Warren as Security Guard

Mike Akrawi as Foreign Dignitary #1

Romeo Akrawi as Foreign Dignitary #2

Jack Coleman as Doctor

Laura Interval as Angela (as Laura Stepp)

Garrison M. Singer as Anesthesiologist

John Koyama as Hong Kong Military Air Base Security (uncredited)

Al Goto as Hong Kong Military Air Base Person (uncredited)

Roger Yuan as Korean Soldier (uncredited)

Angelie Almendare as Diplomat's Wife (uncredited)