Michael Jai White as Mike Tyson

George C. Scott as Cus D'Amato

Paul Winfield as Don King

James B. Sikking as Bill Clayton

Malcolm-Jamal Warner as Rory Holloway

Tony Lo Bianco as Jim Jacobs

Clark Gregg as Kevin Rooney

Holt McCallany as Teddy Atlas

Kristen Wilson as Robin Givens

Sheila Wills as Ruth Roper

Regal Hanley as Young Mike Tyson

Lilyan Chauvin as Camille Ewald

Rebekah Johnson as Desiree Washington

George Murdock as Baranski

Mane Rich Andrew as Young Rodney Tyson

Marta Boyett as Young Teenage Girl

Jimmy Bridges as Carl King

Richard Callender as Johnny Gill

Dayton Callie as Sportswriter #1

Tony Campisi as Sportswriter #2

Reg E. Cathey as Attorney Winston

June Chandler as Barbara Walters

China Chen as Proprietress

Johnnie Cineus as Young Denise Tyson

Richard Kennedy Compton as Michael Hayes

Debra Dusay as Nurse

Sandy Endo as Japanese Girl

Enya Flack as Harlem Girl #3

Al Foster as Rev. Williams

Robert Gould as Sportswriter #3

Jill Tompkins as Candy Striper (uncredited)