Meg Ryan as Eve Mozell Marks

Diane Keaton as Georgia Mozell

Lisa Kudrow as Maddy Mozell

Walter Matthau as Lou Mozell

Adam Arkin as Joe Marks

Jesse James as Jesse Marks

Shaun Duke as Dr. Omar Kunundar

Ann Bortolotti as Ogmed Kunundar

Cloris Leachman as Pat Mozell

Maree Cheatham as Angie

Myndy Crist as Dr. Kelly

Edie McClurg as Esther

Tracee Ellis Ross as Kim

Libby Hudson as Georgia's Assistant (Libby)

Celia Weston as Madge Turner

Stephanie Ittleson as Victoria

Charles Matthau as Young Lou

Paige Wolfe as Six-Year-Old Eve

Katie Stratton as Twelve-Year-Old Georgia

Talia-Lynn Prairie as Four-Year-Old Maddy

Ethan Dampf as Four-Year-Old Jesse Marks

Bob Kirsh as Nixon Library Representative

Kristina Dorn as Young Pat

Venessia Valentino as Nurse at Mesh Window

R.A. Buck as Gay Man

Phil Levesque as Gay Man

Mary Beth Pape as Mother at Party

Catherine Paolone as Doctor

Carol Mansell as Woman Who Recognizes Maddy

Lucky Vanous as Montana Dude

Bill Robinson as Doctor on Soap

Jaffe Cohen as Sub-Editor

Johnathan Cale as Hairdresser

Janet Dey as Event Attendee (uncredited)