Morgan Freeman as Charlie

Renée Zellweger as Betty

Chris Rock as Wesley

Greg Kinnear as Dr. David Ravell

Aaron Eckhart as Del

Tia Texada as Rosa

Crispin Glover as Roy

Pruitt Taylor Vince as Ballard

Allison Janney as Lyla

Kathleen Wilhoite as Sue Ann

Elizabeth Mitchell as Chloe

Susan Barnes as Darlene

Harriet Sansom Harris as Ellen

Sung-Hi Lee as Jasmine

Laird Macintosh as Dr. Lonnie Walsh

Steven Gilborn as Blake

Jenny Gago as Mercedes

Sheila Kelley as Joyce

Matthew Cowles as Merle

Wayne Tippit as Doctor

George D. Wallace as Grandfather

Lesley Woods as Grandmother

Cynthia Martells as Chief Nurse

Alfonso Freeman as ER Doctor

Kevin Rahm as Friend #1

Steven Culp as Friend #2

Deborah May as Gloria Walsh

Max Murphy as Studio Guard

Tina Smith as Waitress

T.J. Kennedy as Cook

Irene Olga López as Rosa's Mother

Steve Franken as Administrator

Kelwin Hagen as Deputy

Josh Dotson as Parking Valet

Dona Hardy as Woman Patient

Paul Threlkeld as Grip

José Vásquez as Gang Member

Jack Jacobson as Stagehand

Elaine Corral Kendall as Anchor

Greg Bronson as Diner Patron (uncredited)

Michelle Carmen Gomez as Woman at Bar (uncredited)

Toby Linz as Sue Ann's Son (uncredited)

Hillary Straney as Woman in Hotel (uncredited)

Jenny Wade as Diner Waitress (uncredited)