Glenn Close as Cruella de Vil

Gérard Depardieu as Jean Pierre Le Pelt

Ioan Gruffudd as Kevin Shepherd

Alice Evans as Chloe Simon

Tim McInnerny as Alonzo

Eric Idle as Waddlesworth (voice)

Ben Crompton as Ewan

Carol MacReady as Agnes

Ian Richardson as Mr. Torte

Jim Carter as Detective Armstrong

Ron Cook as Mr. Button

Timothy West as Judge

David Horovitch as Dr. Pavlov

Dick Brannick as Pavlov's Assistant

Mike Hayley as Constable

Nicholas Hutchison as Reporter

Tim Willcox as ITN Reporter

June Watson as Prison Warden

Tony Bluto as Photocopier Repairman

Tessa Vale as Ticket Seller

John Styles as Punch & Judy Man

Kerry Shale as Le Pelt's Assistant

Thierry Lawson as Le Pelt's Assistant

Hugh Futcher as Brakeman

Charles Simon as Lord Carnivore

Dorothea Phillips as Mrs. Mirthless

Delphine Annaiis as Paris Poodle Lady

Sherwood Ball as Singer (uncredited)

Macéo Bhardwaj as Audience Member (uncredited)

JB Blanc as Police Captain (uncredited)

Ian Boo Khoo as Passenger at Station (uncredited)

Julia Bridgeman as Schoolgirl / Puppy (voice; uncredited)

Greg Bronson as Luncheon Attendee (uncredited)

Martin Brown as TV News Sound Recordist (uncredited)

Rene Costa as Paparazzi (uncredited)

Leilani Holmes as Orient Express Passenger (uncredited)

Karen Kennedy as Social Worker / Driver (uncredited)

Suzy Kewer as French Model (uncredited)

David Keyes as Waddlesworth (voice; uncredited)

Jake Lanning as Delivery Man (uncredited)

Jonathan Lucas as Newscaster (voice; uncredited)

Jack Mason as Boy on Climbing Frame (uncredited)

Ann Mills as Fashion Show Editor (uncredited)

Adriana Nima as Dottie (uncredited)

James Payne as Taxi Driver (uncredited)

Brett Reylander as Chef (uncredited)

Nigel Rixon as Bus Driver (uncredited)