Glenn Close as Cruella de Vil

Jeff Daniels as Roger

Joely Richardson as Anita

Joan Plowright as Nanny

Hugh Laurie as Jasper

Mark Williams as Horace

John Shrapnel as Skinner

Tim McInnerny as Alonzo

Hugh Fraser as Frederick

Zohren Weiss as Herbert

Mark Haddigan as Alan

Michael Percival as Police Inspector

Neville Phillips as Minister

John Evans as Pensioner with Bulldog

Hilda Braid as Woman On Park Bench

Margery Mason as Woman On Park Bench

John Benfield as Doorman

Andrew Readman as Police Officer #1

John Peters as Police Officer #2

Bill Stewart as Arresting Officer

Gerald Paris as Doctor

Joe Lacey as Veterinarian

Brian Capron as Television News Reporter

Harry Fielder as Passerby (uncredited)