Brendan Fraser as George of the Jungle

Leslie Mann as Ursula Stanhope

Thomas Haden Church as Lyle Van de Groot

John Cleese as An Ape Named 'Ape' (voice)

Richard Roundtree as Kwame

Abraham Benrubi as Thor

Holland Taylor as Beatrice Stanhope

John Bennett Perry as Arthur Stanhope

Greg Cruttwell as Max

Kelly Miracco as Betsy

Michael Chinyamurindi as N'Dugo

Abdoulaye N'Gom as Kip

Lydell M. Cheshier as Baleto

Keith Scott as The Narrator (voice)

Spencer Garrett as Male Guest at Party

Jon Pennell as Male Guest at Party

Lauren Bowles as Ursula's Friend

Afton Smith as Ursula's Friend

Samantha Harris as Ursula's Friend

Hans Schoeber as Mercenary

Alexander Denk as Mercenary

Sven-Ole Thorsen as Mercenary

Rodney Louis Johnson as Jailer

Peter F. Giddings as TV Weatherman

Terilyn Joe as TV Anchor

Michel Camus as Cameraman

Valerie Perri as TV Reporter

Carrie Zanoline as Perfume Lady

Garrett Griffin as Fireboat Captain

Harve Cook as Bongo Drummer at Dance Studio

Richard Elfman as Bongo Drummer at Dance Studio

Denise Holland as Dancer

Anne Fletcher as Dancer

Kristie Capozzoli as Dancer

Sal Vassalo as Dancer

Diane Mizota as Dancer

Melanie Gage as Dancer

Aurorah Allain as Dancer

Lisa Ratzin as Dancer

Joie Shettler as Dancer

Sharon Ferrol-Young as Dancer

Tara Nicole Hughes as Dancer

Robin Tasha-Ford as Dancer

Margo Blas as Caterer

Jake Gentry as Caterer with Tray

Tim Glenn as Waiter

Jewel McDonald as Shop Owner

Bob Quinn as Party Attendant

Tai the Elephant as Shep

Binx the Monkey as Little Monkey

Joseph the Lion as Lion

Caleb the Lion as Lion

Bongo the Lion as Lion

Caesar the Lion as Lion (uncredited)

Crystal the Monkey as Monkey (uncredited)

Frank Welker as Lion/Little Monkey/Shep/Tooki Tooki Bird/Gorilla sound effects(voice) (uncredited)

Mary Ann Schmidt as Customer at Department Store (uncredited)

Tress MacNeille as Shep (voice) (uncredited)