Lacey Chabert as Eliza Thornberry (voice)

Jodi Carlisle as Marianne Thornberry (voice)

Tim Curry as Nigel Thornberry (voice)

Flea as Donald 'Donnie' Michael Thornberry (voice)

Danielle Harris as Debbie Thornberry (voice)

Tom Kane as Darwin (voice)

Betty White as Grandma Sophie (voice)

Alan Henry Brown as Sri Mayasandra (voice)

Arthur Burghardt as Rhino / Monkey (voice)

Cara DeLizia as Baru / Monkey (voice)

Moira Quirk as Rehabilitation Worker / Monkey (voice)

Dwight Schultz as Badouk / Monkey / Poacher (voice)

Tuan Tran as Kickboxing Instructor (voice)

Alfre Woodard as Medicine Woman (voice)

Dee Bradley Baker as Parrots (voice)

Patti Deutsch as Female Rhinoceros Hornbill (voice)

Clyde Kusatsu as Sun Bear (voice)

David Paymer as Male Rhinoceros Hornbill (voice)

Maureen Quinn as Lugan (voice)

Pamela Adlon as Saiful (voice)

Jusak Bernhard as Tribal Man / Villager / Poacher (voice)

Denny Chandra as Villager (voice)

Tania Gunadi as Villager / Forest Animal (voice)

Malik Nasution as Villager (voice)

Benny Tjandra as Villager (voice)

Earl Boen as Bearded Pig / Poacher (voice)

Leila Kenzle as Squirrel / Forest Animal (voice)

Candi Milo as Civat Cat / Mousedeer / Forest Animal (voice)

Pat Musick as Ona / Owl / Forest Animal (voice)

Julia Nickson as Villager / Forest Animal / Donnie's Mother (voice)

Amy Hill as Ibu (voice)

Michael Moertl as Villager / Donnie's Father (voice)