Rob Paulsen as Yakko Warner / Pinky / Dr. Otto Scratchansniff (voice)

Jess Harnell as Wakko Warner (voice)

Tress MacNeille as Dot Warner / Marita Hippo / Hello Nurse / Mindy's Mother (voice)

Maurice LaMarche as Brain / Squit (voice)

Nancy Cartwright as Mindy (voice)

Frank Welker as Various (voice)

Chick Vennera as Pesto (voice)

John Mariano as Bobby / Gas Station Attendant (voice)

Bernadette Peters as Rita (voice)

Sherri Stoner as Slappy Squirrel (voice)

Paxton Whitehead as King Salazar (voice)

Ben Stein as Desire Fulfillment Facilitator (voice)

Jeff Bennett as Captain of the Guard / Baloney (voice)

Paul Rugg as Mr. Director (voice)

Julie Brown as Minerva Mink (voice)

Tom Bodett as Narrator (voice)

Julie Bernstein as Singer (voice)

Steven Bernstein as Singer (voice)

Bobbi Page as Singer (voice)

Nathan Ruegger as Skippy Squirrel (voice)