Danny Trejo as Machete Cortez

Mel Gibson as Luther Voz

Demián Bichir as Mendez

Amber Heard as Blanca Vasquez / Miss San Antonio

Michelle Rodriguez as Luz

Sofía Vergara as Desdemona

Charlie Sheen as Mr. President

Jessica Alba as Sartana Rivera

Lady Gaga as La Camaleon

Alexa PenaVega as KillJoy

Vanessa Hudgens as Cereza Desdemona

Tom Savini as Osiris Amanpour

Cuba Gooding Jr. as El Camaleon

Antonio Banderas as El Camaleon

Walton Goggins as El Camaleon

William Sadler as Sheriff Doakes

Marko Zaror as Zaror

Julio Oscar Mechoso as Chepo

Billy Blair as Billy

Samuel Davis as Clebourne

Felix Sabates as Doc Felix

Electra Avellan as Nurse Mona

Elise Avellan as Nurse Lisa

Marci Madison as Nurse Fine

Callie Hernandez as Space Babe

Alejandro Antonio as Boss of Mendez

Crystal Martinez as Wife of Mendez

Corey Burton as Trailer Voice Guy (voice)

Elon Musk as Elon Musk

Emmy Robbin as Pris

Jason Christopher as Lieutenant Brass

Sam Medina as Cartel Leader

J.J. Perry as Voz's Henchman (uncredited)

Alexander Rodnyansky as Radio Guest (uncredited)

Vincent Fuentes as Cabrito Cook

Elle LaMont as Dollface

Jorge A. Jimenez as Dying Cartel Guy