Brendan Fraser as DJ Drake / Tasmanian Devil (voice) / She-Devil (voice) / Self

Jenna Elfman as Kate

Steve Martin as Mr. Chairman

Joe Alaskey as Bugs Bunny-Daffy Duck / Beaky Buzzard / Sylvester / Mama Bear (voice)

Jeff Bennett as Yosemite Sam / Foghorn Leghorn / Nasty Canasta (voice)

Timothy Dalton as Damien Drake

Billy West as Elmer Fudd / Peter Lorre (voice)

Heather Locklear as Dusty Tails

Joan Cusack as Mother

Bill Goldberg as Mr. Smith

Don Stanton as Mr. Warner

Dan Stanton as Mr. Warner's Brother

Dick Miller as Security Guard

Roger Corman as Hollywood Director

Kevin McCarthy as Dr. Bennell

Jeff Gordon as Self

Matthew Lillard as Self

Mary Woronov as Acme VP, Bad Ideas

Marc Lawrence as Acme VP, Stating the Obvious

Bill McKinney as Acme VP, Nitpicking

George Murdock as Acme VP, Unfairly Promoted

Robert Picardo as Acme VP, Rhetorical Questions

Ron Perlman as Acme VP, Never Learning

Vernon Wells as Acme VP, Child Labor

Leo Rossi as Acme VP, Climbing to the Top

Archie Hahn as Stunt Director

Allan Graf as Interrogator

Austyn Cuccia as Tour Bus Girl

Marie-Claude Jacques as Flower Vendor

Michael Azria as Paris Cafe Waiter

Dan Romanelli as Studio Executive

Ryan O'Dell as Bugs Bunny Driver

Kevin Thompson as Dancing Yosemite Sam

Arturo Gil as Dancing Yosemite Sam

Gabriel Pimentel as Dancing Yosemite Sam

Steve Babiar as Dancing Yosemite Sam

Martin Klebba as Dancing Yosemite Sam

Eric Goldberg as Tweety Bird / Marvin the Martian / Speedy Gonzalez (voice)

Bruce Lanoil as Pepe le Pew (voice)

June Foray as Granny (voice)

Bob Bergen as Porky Pig (voice)

Casey Kasem as Shaggy (voice)

Frank Welker as Scooby-Doo (voice)

Danny Chambers as Cottontail Smith (voice)

Stan Freberg as Baby Bear (voice)

Will Ryan as Papa Bear (voice)

Danny Mann as Robo Dog - Spy Car (voice)

Mel Blanc as Gremlin Car (archive sound)

Tara Wilson as Dancer

Tanee McCall as Dancer

Gelsey Weiss as Dancer

Brenda Mae Hamilton as Dancer

Liz Ramos as Dancer

Emily Rose Zachary as Dancer

Becca Sweitzer as Dancer

Janina Garraway as Dancer

Alysha Wheeler as Dancer

Micki Duran as Dancer

Chi Johnson as Dancer

Shealan Spencer as Dancer

Shanti Lowry as Dancer

Brandon Henschel as Dancer

Erica Gudis as Dancer

John Munro Cameron as The Man from Planet X

Peter Graves as Host of Civil Defense Film

Glen Hambly as Laboratory Scientist

Michael Jordan as Self (archive footage)

Louis Kiss as Dalek

Nikki Martin as Wooden Nickel Waitress

Laura Orrico as Secret Agent Shopper

Robert Parigi as Robby the Robot

Dean Ricca as Studio Tour Guide

Tom Woodruff Jr. as The Metaluna Mutant (uncredited)