E. G. Daily as Tommy Pickles (voice)

Christine Cavanaugh as Chuckie Finster (voice)

Cheryl Chase as Angelica Pickles (voice)

Susan Sarandon as Coco LaBouche (voice)

John Lithgow as Jean-Claude (voice)

Tara Strong as Dil Pickles (voice)

Kath Soucie as Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell as Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer as Susie Carmichael (voice)

Tress MacNeille as Charlotte Pickles (voice)

Debbie Reynolds as Lulu Pickles (voice)

Joe Alaskey as Grandpa Lou Pickles (voice)

Mako as Mr. Yamaguchi (voice)

Tim Curry as Sumo Singer (voice)

Julia Kato as Kira Watanabe-Finster (voice)

Billy West as Sumo Singer (voice)

Dionne Quan as Kimi Watanabe-Finster (voice)

Melanie Chartoff as Didi Pickles (voice)

Casey Kasem as Wedding DJ (voice)

Phil Proctor as Howard DeVille (voice)

Lisa McClowry as Princess (voice)

Dan Castellaneta as Priest (voice)

Roger Rose as Finster Wedding DJ (voice)

Kevin Michael Richardson as Sumo Singer (voice)

Jack Riley as Stu Pickles (voice)