Anthony Hopkins as John Casey

William H. Macy as Paul Ebbers

Harry Belafonte as Nelson

Freddy Rodríguez as José Rojas

Laurence Fishburne as Edward Robinson

Heather Graham as Angela

Lindsay Lohan as Diane

Shia LaBeouf as Cooper

Christian Slater as Daryl Timmons

Sharon Stone as Miriam Ebbers

Helen Hunt as Samantha Stevens

Emilio Estevez as Tim Fallon

Demi Moore as Virginia Fallon

Nick Cannon as Dwayne

Joshua Jackson as Wade

Jacob Vargas as Miguel

Brian Geraghty as Jimmy

Svetlana Metkina as Lenka Janáček

Elijah Wood as William Avary

Joy Bryant as Patricia

Mary Elizabeth Winstead as Susan Taylor

David Krumholtz as Agent Phil

Ashton Kutcher as Fisher

Martin Sheen as Jack Stevens

Spencer Garrett as David

Scoot McNairy as Beatnik

Gene Borkan as Salesman

David Kobzantsev as Sirhan Sirhan

Dave Fraunces as Robert F. Kennedy

Robert F. Kennedy as Self (archive footage)

John F. Kennedy as Self (archive footage)

Ted Kennedy as Self (archive footage)

Martin Luther King Jr. as Self (archive footage)