Seann William Scott as Doug Stauber

John C. Reilly as Richard Wehlner

Jenna Fischer as Jen Stauber

Lili Taylor as Lori Wehlner

Gil Bellows as Mitch

Rick Gonzalez as Ernesto

Adrian Martinez as Octavio

Fred Armisen as Scott Fargas

Bobby Cannavale as Dr. Timms

Masi Oka as Realtor

Jason Bateman as Retreat Leader

Ithamar Enriquez as Rogelio

Blair Lewin as Pedestrian (uncredited)

Chris Conrad as Teddy Grahams

David Charles DuBois as Doctor