Keri Russell as Jenna Hunterson

Nathan Fillion as Dr. Jim Pomatter

Andy Griffith as Old Joe

Cheryl Hines as Becky

Adrienne Shelly as Dawn Williams

Jeremy Sisto as Earl Hunterson

Eddie Jemison as Ogie Anhorn

Lew Temple as Cal

Darby Stanchfield as Francine Pomatter

Cindy Drummond as Hospital Nurse

Lauri Johnson as Nurse Norma

Nathan Dean as Minister

Heidi Sulzman as Exhausted Mother

Sarah Hunley as Dr. Lily Mueller

Caroline Fogarty as Doctor's Assistant

Christy Taylor as Pregnant Woman #1

Jennifer Walsh as Pregnant Woman

Mackenzie King as Flower Girl

Hunter A. King as Obnoxious Toddler

Donna Leslie as Char

Andy Ostroy as Cake Man

Sophie Ostroy as Lulu as Toddler

Holgie Forrester as Dawn's Mother

Nora Paradiso as Ethel