Kirstie Alley as Marjorie Turner

Bill Pullman as Nicholas Meany

Carrie Fisher as Iris Turner-Hunter

Jami Gertz as Jeanine

Scott Bakula as Harry Turner

Frances Sternhagen as Rose Turner

John Randolph as Charles Turner, Sr.

Sam Elliott as Charles Turner, Jr.

Ed O'Neill as Wilbur Meany

Bill Macy as Pat

Matthew Laurance as Dr. Casey Hunter

Paul Benedict as Dr. Plotner

Ron Orbach as Don, the Desk Clerk

Edward Escobar as 911 Officer

Greg Collins as Hotel Security Guard

Patrick Cronin as Gary Diamond

Dian Kobayashi as Market Cashier

Teddy M. Haggarty as Roger, the Salesman

Roy Van Swearingen as Mayor

Ken Grantham as Minister

Dan Sachoff as Doorman

Sean C. Ching as Delivery Man

Bob Harks as Priest

Adele Proom as Hostess

Heather Marie Wierman as Patient

Maurine Houck as Aunt Rose

Crystan Leas as Young Marjorie

Yvonne De Barca as Young Jeanine