Eric Judor as Joe

Ramzy Bedia as Averell

Saïd Serrari as Jack

Til Schweiger as Lucky Luke

Jean Dujardin as Le Cow-Boy Vanneur

Javivi as El Tarlo

Marthe Villalonga as Ma Dalton

Romain Berger as William

Michel Muller as Le Directeur de la Banque

Élie Semoun as Doxey / Le douanier américain / Le douanier mexicain

Kad Merad as Le Mexicain Cellule

Marie-Pierre Casey as Ma Cassidy

Constantine Attia as Le Gros Bandit

Arsène Mosca as Le Grand Bandit

Ginette Garcin as Ma James

Ismael Fritschi as Le Patron du Saloon

Jean Benguigui as Le Chef de Village

Sylvie Joly as Ma Billy

Clovis Cornillac as Le gardien de prison

François Hadji-Lazaro as L'épicier

Jean Rochefort as Jolly Jumper (voice)

Eric Métayer as Rantanplan (voice)