Mark Ruffalo as Adam

Gwyneth Paltrow as Phoebe

Tim Robbins as Mike

Josh Gad as Neil

Pink as Dede

Patrick Fugit as Danny

Joely Richardson as Katie

Carol Kane as Roberta

Emily Meade as Becky

Isiah Whitlock, Jr. as Charles

Poorna Jagannathan as Lili Kazhani

Tony Joe as Mail executive

Jordan Dean as Jordan

Michaela Watkins as Margo

Okieriete Onaodowan as Lou

Natalia Volkodaeva as Ana

Paul Urcioli as Owner

Kenneth Maharaj as Cabbie

Meng Ai as Mini-Mart Cashier

Juan Leon as Cashier

Geoffrey Molloy as Mustache Man

Maureen Sebastian as Subway Woman

Marcus Neville as Peter

Sarah Baskin as Waitress

Alexis Suarez as Paramedic

Terry Walters as Female Addict

George Demas as Addict

David Wain as Addict

Brian Koppelman as Addidct

Geoffrey Cantor as Addict

Gary Silberman as Meeting Man

Ben Boime as Meeting Man

Linn Yen as Beautiful Woman

Andre Ward as Kai (uncredited)