Toni Collette as Ellie Klug

Thomas Haden Church as Charlie

Oliver Platt as Giles

Ryan Eggold as Lucas Stone

Nina Arianda as Dana

Ahna O'Reilly as Charlotte

Johnny Depp as Matthew Smith

Joanne Woodward as Doris (voice)

Amy Seimetz as Sara

S.J. Chiro as Giles' Wife

Lynn Shelton as Lisa

Louis Hobson as Lawrence

Christian Palmer as Bartender

Conner Marx as Micah

Evan Mosher as Joshua

Richard Carmen as Farmer

Tony Doupe as Jonathan

Emily Wachtel as Charity Rocks

Sean Nelson as Declan P. MacManus

Jake Robards as Leonard Paul

Faustine Hudson as Self

Michael Bama Katt as Doug

Matthew Emerson Brown as Lucas' Band / Lap Steel

Evan Flory-Barnes as Lucas' Band / Upright Bass

Garrett Hobba as Lucas' Band / Harmony

Aliya Hashemi as Waitress

Wally Dalton as George Smith

Linas Phillips as Anglar

Michael DeVito as Wedding Bartender

Kevin Seal as Justice of the Peace

Gary Gulman as Craig

Mary E. Quick as Wendy

Joey Ally as Bridesmaid

Aron Michael Thompson as Groomsman

Dave Galafassi as Club Drummer

Carollani Sandberg as Smoking Girl

John Totten as Drummer

Stefan Hayek as Guitarist