Will Smith as Ben

Rosario Dawson as Emily

Woody Harrelson as Ezra Turner

Michael Ealy as Ben's Brother

Barry Pepper as Dan

Elpidia Carrillo as Connie

Robinne Lee as Sarah

Bill Smitrovich as George Ristuccia

Joe Nuñez as Larry

Sarah Jane Morris as Susan

Connor Cruise as Young Ben

Tim Kelleher as Stewart Goodman

Gina Hecht as Dr. Briar

Andy Milder as George's Doctor

Judyann Elder as Holly

Madison Pettis as Connie's Daughter

Octavia Spencer as Kate the Home Health Care Nurse

Robert Ochoa as Choirboy (uncredited)

Bojana Novaković as Julie

Sonya Eddy as Nurse

Nichole Ambriz as OR Nurse