Robert De Niro as Rodrigo Mendoza

Jeremy Irons as Father Gabriel

Ray McAnally as Cardinal Altamirano

Aidan Quinn as Felipe Mendoza

Liam Neeson as Father John Fielding

Cherie Lunghi as Carlotta

Ronald Pickup as Hontar

Chuck Low as Don Cabeza

Bercelio Moya as Indian Boy

Sigifredo Ismare as Witch Doctor

Daniel Berrigan as Sebastian

Carlos Duplat Sanjuan as Portuguese Commander

Fred Melamed as Don Cabeza (voice) (uncredited)

Rolf Gray as Un jeune jésuite

Tony Lawn as Père Provincial

Monirak Sisowath as Ibaye

Asuncion Ontiveros as Le chef indien

Alejandrino Moya as Le lieutenant

Álvaro Guerrero as Jesuit

Joe Daly as Nobleman

Rafael Camerano as Spanish Commander

Silvestre Chiripua as Indian

Luis Carlos Gonzalez as Boy Singer

Maria Teresa Ripoll as Carlotta's Maid

Alberto Borja as Priest (uncredited)

Alain Becerra Calderon as Portuguese Soldier (uncredited)

Jacques Des Grottes as Priest (uncredited)

Enrique Lamas as Nobleman (uncredited)

Fred Melamed as Cabeza (voice) (uncredited)

Antonio Segovia as Nobleman (uncredited)

Harlan Venner as Secretary (uncredited)