Chevy Chase as Clark Griswold

Beverly D'Angelo as Ellen Griswold

Randy Quaid as Cousin Eddie

Ethan Embry as Russell 'Rusty' Griswold

Marisol Nichols as Audrey Griswold

Miriam Flynn as Cousin Catherine

Shae D'Lyn as Cousin Vicki

Wayne Newton as Himself

Siegfried Fischbacher as Siegfried

Roy Horn as Roy

Wallace Shawn as Marty

Sid Caesar as Mr Ellis

Julio Oscar Mechoso as Limo Driver

Sly Smith as Mirage Security Guard

Julia Sweeney as Mirage Reception Person

Corinna Harney as Girl at Blackjack Table

Joe Armeno as Roulette Stickman

Christie Brinkley as Woman in Ferrari

Juliette Brewer as Cousin Ruby Sue

Zachariah Moyes as Cousin Denny

John Finnegan as Hoover Dam Guide

Howard Platt as Maitre'd

Maria Cina as Mirage Cashier

Wendy Kaufman as Wendy

Joe Lacoco as Riviera Bartender

C.C. Costigan as Kelli

Shannah Laumeister Stern as Mariah

Bud Ekins as O'Shea's Security Guard

Gary Devaney as Croupier #2

Jerry Weintraub as Jilly

S.A. Griffin as Pit Boss

Lou DiMaggio as Casino Host

Ruth Gillis as Saleswoman

Jason Stuart as Buffet Guy

Frank Washko Jr. as Guess Which Hand Dealer

Clinton Brandhagen as Valet

Hayley Mortison as Girl in Hot Tub

Rusty Meyers as Club Manager

Billy Morrissette as Paramedic #1

Sharon Mendel as Paramedic #2

Larry Hankin as Preacher

Alana Austin as Tourist (uncredited)

Vanessa Bednar as Hot Pool Model (uncredited)

JoAnn Bush as Flight Attendant (uncredited)

Jeffrey Donovan as Hotel Employee (uncredited)

Billie Perkins as Casino Guest (uncredited)

Toby Huss as Fake I.D. Salesman