Chevy Chase as Clark Griswold

Beverly D'Angelo as Ellen Griswold

Juliette Lewis as Audrey Griswold

Johnny Galecki as Russell 'Rusty' Griswold

John Randolph as Clark, Sr.

Diane Ladd as Nora

E.G. Marshall as Art

Doris Roberts as Francis

Randy Quaid as Cousin Eddie

Miriam Flynn as Cousin Catherine

Cody Burger as Rocky

Ellen Hamilton Latzen as Ruby Sue

William Hickey as Uncle Lewis

Mae Questel as Aunt Bethany

Sam McMurray as Bill

Nicholas Guest as Todd Chester

Julia Louis-Dreyfus as Margo Chester

Nicolette Scorsese as Mary

Keith MacKechnie as Delivery Boy

Brian Doyle-Murray as Frank Shirley

Natalija Nogulich as Helen Shirley

Tony Epper as Bozo #1

Billy Hank Hooker as Bozo #2

Alexander Folk as SWAT Officer

Jeremy Roberts as Cop

Woody Weaver as Cop

Michael Kaufman as Young Executive

Doug Llewelyn as Parade Announcer (voice)

Devin Bailey as Clark (age 9) (uncredited)

Frank Foti Jr. as SWAT Team Sargeant (uncredited)

Traci Kochendorfer as Downtown Shopper (uncredited)