Dustin Hoffman as Narrator (voice)

Sara Lewinstein as Storyteller (Story Subject: Dr. Tom Waddell)

David Mandell as Storyteller (Story Subject: David Mandell Jr.)

Suzi Mandell as Storyteller (Story Subject: David Mandell Jr.)

Sallie Perryman as Storyteller (Story Subject: Robert Perryman)

Vito Russo as Storyteller (Story Subject: Jeffrey Sevcik)

Tracy Torrey as Storyteller (Story Subject: Self and David C. Campbell)

Gregg Baker as Self - News Reporter (archive footage)

Gary Bauer as Self - Policy Advisor to the President (archive footage)

Robert Bazell as Self - News Reporter (archive footage)

Kevin Boyle as Self - News Reporter (archive footage)

Edward Brandt as Self - Assistant Secretary for Health (archive footage)

Tom Brokaw as Self - News Reporter (archive footage)

Bobbi Campbell as Self (archive footage)

David C. Campbell as Self (archive footage)

Marcus A. Conant as Self (archive footage)

James Curran as Self - Center for Disease Control (archive footage)

Bolton Eckert as Self - News Reporter (archive footage)

Jerry Falwell as Self - Moral Majority Leader (archive footage)

Virginia Fedosky as Self (archive footage)

Emil Guillermo as Self - News Reporter (archive footage)

Bryant Gumbel as Self - News Reporter (archive footage)

Tim Haas as Self - News Reporter (archive footage)

Robert Hager as Self - News Reporter (archive footage)

Charles Howard as Self (archive footage)

Rock Hudson as Self (archive footage)

Cleve Jones as Self

C. Everett Koop as Self - Surgeon General (archive footage)

Larry Kramer as Self (archive footage)

Roger Gail Lyon as Self (archive footage)

David Mandell Jr. as Self (archive footage)

Kevin McCullough as Self - News Reporter (archive footage)

Andrea Mitchell as Self - News Reporter (archive footage)

Eddie Murphy as Self (archive footage)

Mark Ostfield as Self (archive footage)

Marcia Pally as Self - News Reporter (archive footage)

John Palmer as Self - News Reporter (archive footage)

Hampton Pearson as Self - News Reporter (archive footage)

Robert Perryman as Self (archive footage)

John Politano as Self

Josie Politano as Self

Randy Ray as Self (archive footage)

Robert Ray as Self (archive footage)

Ricky Ray as Self (archive footage)

Ronald Reagan as Self (archive footage)

Neil Schram as Self - Los Angeles AIDS Task Force (archive footage)

Heidi Schulman as Self - News Reporter (archive footage)

Jeffrey Sevcik as Self (archive footage)

Elizabeth Taylor as Self - Introduction Speaker

Tom Waddell as Self (archive footage)

Gary Walsh as Self (archive footage)

James Watkins as Self - Presidential AIDS Commission (archive footage)

Linda Yee as Self - News Reporter (archive footage)