Martin Lawrence as Malcolm Turner / Big Momma

Marisol Nichols as Liliana Morales

Kevin Durand as Oshima

Dan Lauria as Crawford

Kat Dennings as Molly Fuller

Josh Flitter as Stewart

Zachary Levi as Kevin Keneally

Jascha Washington as Trent

Jeanene Fox as Yasmeen

Mark Moses as Tom Fuller

Chloë Grace Moretz as Carrie Fuller

Emily Procter as Leah Fuller

Nia Long as Sherri

Lisa Arrindell as Danielle (as Lisa Arrindell Anderson)

Bryan James Kitto as Trent's Friend

Luke Ramsey as FBI Agent #1

Lonnie Lamont as FBI Agent #2

Marcus Lyle Brown as Erskine

Mehera Blum as Fuller's Secretary, Lucy

Shanna Moakler as Petra

Yuji Okumoto as Parsons

Yvonne Landry as Isabella

Lisa Arrindell as Danielle

Wendy Braun as Coach Bonnie

Ann Mahoney as Coach Lisa

Deneen Tyler as Tassie

Max Van Ville as Chad

Sean Lampkin as Cabbie

William Ragsdale as Bob

Kelly Dowdle as Surf Shop Girl

Jessica White as Bra Model

Amy Morris as Spa Susan

Michelle Parylak as Spa Joanne

Deena Dill as Spa Crystal

Paige Butcher as Background Model

Lucy Wolvert as Background Model

Tim Soergel as Speedo Guy

Jessica Anderson as Bikini Girl

Breanna Startzel as Girl in Bikini

Preston Shores as Andrew

Trevor Shores as Andrew

Sarah Joy Brown as Constance

Adrian Staton as Sandy (uncredited)