Martin Lawrence as Malcolm / Big Momma

Brandon T. Jackson as Trent / Charmaine

Jessica Lucas as Haley

Michelle Ang as Mia

Portia Doubleday as Jasmine Lee

Emily Rios as Isabelle

Ana Ortiz as Headmistress

Henri Lubatti as Vlad

Lorenzo Pisoni as Dmitri

Tony Curran as Chirkoff

Marc John Jefferies as Rembrandt

Brandon Gill as Scratch

Zack Mines as Delante

Rhett Lindsey as TJ

Ken Jeong as Mailman

Max Casella as Canetti

Susan Walters as Mall Mother

Sherri Shepherd as Beverly Townsend

Susan Griffiths as Cafeteria Girl #1

Brianne Gould as Cafeteria Girl #2

Dawntavia Marrero as Cafeteria Girl - Another Girl

Mari Morrow as Dance Instructor

Susie Spear Purcell as Art Teacher

Lily Chambers as Drama Queen #1

Jasmine Burke as Drama Queen #2

Juliet Kim as Quad Student

Brian Lafontaine as Crawford

Ramsey Luke as FBI Agent

Jazmia Battle as Diva #1

Christiani Pitts as Diva #2

C.J. Perry Barnyashev as Dancer (uncredited)

G. Christopher Carson as Art Patron (uncredited)

Nilsa Castro as Audience Spectator (uncredited)

Chenique Charmaine as Cafeteria Dancer (uncredited)

Reginald Lashaun Clay as FBI Agent (uncredited)

Sarah Reagin Clemmensen as Art student (uncredited)

Matthew L. Collins as Mall Patron (uncredited)

Tiffany Cosey as Art Student (uncredited)

Michael L. Covington as Parent (uncredited)

Orlando Vargas Diaz as FBI Agent (uncredited)

Niki Edwards as Art Student (uncredited)

Rodney Edwards as Lug Head (uncredited)

Curtis Gammage as Audience Spectator (uncredited)

Jon Gould as Theatre Patron (uncredited)

Joel Harold as Trent Friend (uncredited)

Keith Allen Hayes as Parent (uncredited)

Princess Ja'net as Dancer (uncredited)

Angel Jackson as Student (uncredited)

Alphonse A. Lambert, Jr. as Parent (uncredited)

Faizon Love as Kurtis Kool (uncredited)

Thina Lowe as Student (uncredited)

Carmen Matheny as Core Student (uncredited)

Chantal Maurice as Cafeteria Dancer (uncredited)

Ken Melde as Russian Mobster (uncredited)

Rachelle Neal as Girls School Dancer (uncredited)

Katherine Neslund as High School Student (uncredited)

Lexi Noel as Student Dancer (uncredited)

Kayla Perkins as Student (uncredited)

Greg Perrow as Football Player (uncredited)

Justin Price as Lug Head (uncredited)

Eddie Rattanasouk as Audience Member (uncredited)

Cody Rowlett as Russian (uncredited)

Little Sebastien as Parent at recital (uncredited)

Joshua Tanksley as Audience Member (uncredited)

Mallory Teplinskiy as High School Student (uncredited)

Lisa Marie Thomas as H.S. Arts Student (uncredited)

Steve Warren as GGSA Showcase Audience Member (uncredited)

Deonna Young as Dancer (uncredited)