Rainn Wilson as Randy

Lil Rel Howery as Mike

Aimee Carrero as Jessica

Yvette Nicole Brown as Shanice

Rob Riggle as Dr. Serano

Page Kennedy as Officer Taggert

Xolo Mariduena as Rookie

Eric Jungmann as Nurse Chad

Ayesha Harris as Kim

Luka Jones as Motorcycle Matt

Andy Milder as Bruce

Dalia Rooni as Rachel

Cameron Fuller as Jimmy

Michael J. Sielaff as Johnny

Joaquin Veizaga as Vicente

Liam Oh as Chip (uncredited)

Michael Monks as Officer White

Patrick Pianezza as Paramedic Patrick

Rafael Castillo as Charlie (Mr. President)

Tree O'Toole as Heroin Addict

Therese McLaughlin as Crazy Woman

Peter Holden as Angry White Guy

Melissa Bailey as Charge Nurse

Treisa Gary as Nurse Ruth

Sierra Swartz as Jenna - Sorority Girl

Juan Pacheco as Baseball Coach

Omar Leyva as Vicente's Uncle

Aimee Li as Nurse Colette

Andriana Garbiso as ER Nurse

Adam Mondschein as Drunk Rocky