John Wayne as Lt. Col. Kirby Yorke

Maureen O'Hara as Mrs. Kathleen Yorke

Ben Johnson as Trooper Travis Tyree

Claude Jarman Jr. as Trooper Jefferson 'Jeff' Yorke

Harry Carey, Jr. as Trooper Daniel 'Sandy' Boone

Chill Wills as Dr. Wilkins

J. Carrol Naish as Lt. Gen. Philip Sheridan

Victor McLaglen as Sgt. Maj. Timothy Quincannon

Grant Withers as U.S. Deputy Marshal

Peter Ortiz as Capt. St. Jacques

Steve Pendleton as Capt. Prescott

Karolyn Grimes as Margaret Mary

Alberto Morin as Lieutenant

Stan Jones as Sergeant

Fred Kennedy as Trooper Heinze

Ken Curtis as Donnelly - Regimental Singer (uncredited)

Tommy Doss as Regimental Singer (uncredited)

Hugh Farr as Regimental Singer (uncredited)

Karl Farr as Regimental Singer (uncredited)

Shug Fisher as Regimental Singer/Bugler (uncredited)

Cliff Lyons as Soldier (uncredited)

Lee Morgan as Minor Role (uncredited)

Jack Pennick as Sergeant (uncredited)

Lloyd Perryman as Regimental Singer (uncredited)

Chuck Roberson as Officer / Indian Fires Arrow Into Col. York's Chest (uncredited)

Barlow Simpson as Indian Chief (uncredited)

Patrick Wayne as Boy (uncredited)