Eddie Murphy as Pluto Nash

Randy Quaid as Bruno

Rosario Dawson as Dina Lake

Joe Pantoliano as Mogan

Jay Mohr as Tony Francis

Luis Guzmán as Felix Laranga

James Rebhorn as Belcher

Peter Boyle as Rowland

Burt Young as Gino

Miguel A. Núñez Jr. as Miguel

Pam Grier as Flura Nash

John Cleese as James

Victor Varnado as Kelp

Illeana Douglas as Dr. Mona Zimmer

Jacynthe René as Babette

Alissa Kramer as Gina Francis

Heidi Kramer as Filomina Francis

Lillo Brancato as Larry

Alex Sol as Tommy

Doug Spinuzza as Doug

Andrée Fafard as Holographic Spokesmodel

Stu 'Large' Riley as Club Pluto Bouncer

Roc LaFortune as Jimmy

Russell Yuen as Oliver

Bill Corday as Roy

Angela Perzow as Robot Maid

Ezra Franklyn as Robot Thug

Don Jordan as Reporter

Lorca Simons as Pretty Reporter

Eric Hoziel as Johnson

Christopher Bregman as Michalak

Marlon Sterling Long as Lindsey (as Marlon Long)

Mary C. Hammett as Holographic Nurse

Serge Houde as FBI Agent

Jonathan Stark as Desk Clerk

Terry Haig as Security Guard

Roger E. Reid as Pit Boss

Michael Rudder as Croupier

Alex Bisping as Ted Jefferies (as Alexandre Bisping)

Cornelia Sharpe as Tony Francis Fan (as Cornelia Sharpe Bregman)

Mark Camacho as Robot Holding Cell Clerk

Lana Underwood as Sexy Robot

Alec Baldwin as M.Z.M

Linda E. Smith as Dr. Runa Pendanken (uncredited)

Patrick Kerton as Colins (uncredited)

Brian D. Wright as Ed (uncredited)

Brent Donnelly as FBI Agent Spears (uncredited)

Marc Gourdeau as FBI Inspector (uncredited)

Audrey Wasilewski as Waitress (uncredited)

Michael Challenger as Dancer (uncredited)

Elisabetta Fantone as Dancer (uncredited)