Charlie Sheen as Dex Dogtective (voice)

Hilary Duff as Sunshine Goodness (voice)

Eva Longoria as Lady X (voice)

Wayne Brady as Daredevil Dan (voice)

Christopher Lloyd as Mr. Clipboard (voice)

Chris Kattan as Polar Penguin (voice)

Larry Miller as Vlad Chocool (voice)

Ed Asner as Mr. Leonard (voice)

Jerry Stiller as General X (voice)

Martin Klebba as General X / Kaptain Krispy (voice)

Christine Baranski as Hedda Shopper (voice)

Lawrence Kasanoff as Cheasel T. Weasel (voice)

Harvey Fierstein as Fat Cat Burglar (voice)

Cloris Leachman as Brand X Lunch Lady (voice)

Haylie Duff as Sweet Cakes (voice)

Shelley Morrison as Lola Frutola (voice)

Edie McClurg as Mrs. Butterworth (voice)

George Johnsen as Kaptain Krispy / Hairless Hamster Henchman (voice)

Greg Ellis as Hairy Hold (voice)

James Arnold Taylor as Dr. Si Nustrix / Additonal Voices (voice)

Robert Costanzo as Maximilius Moose (voice) (as Bobby Constanza)

Jeff Bennett as Lieutenant X/Additional Voices (voice)

Stephen Stanton as Mr. Clean / Lord Flushington / Additional Voices (voice)

Jeff Bergman as Charlie Tuna (voice)

Karen Gallo Messore as Blue (voice)

Sean Catherine Derek as Toddler's Mom (voice)

Enn Reitel as Kung Tofu / Fracois Fromage (voice)

Daniel Franzese as Twinkleton (voice)

Eliza Schneider as Sweet Older Lady (voice)

Jason Ortenberg as Ike Kid #1 (voice)

Zachary Liebrich-Johnsen as Ike Kid #2 (voice)

Andrew Ortenberg as Ike Kid #3 (voice)

Jennifer Keith as Ike Kid #4 / Additional Voices (voice)

Joshua Wexler as Hairless Hamster Henchman (voice)

Jason Harris as Hairles Hamster Henchman (voice)

Greg Eagles as Hairless Hamster Henchman (voice)

Melissa Disney as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Susan Silo as Additional Voices (voice)

Daniel Bernhardt as Additional Voices (voice)

John Bloom as Additonal Voices (voice)