Elizabeth Hartman as Mrs. Brisby (voice)

Derek Jacobi as Nicodemus (voice)

Arthur Malet as Mr. Ages (voice)

Dom DeLuise as Jeremy (voice)

Hermione Baddeley as Auntie Shrew (voice)

Shannen Doherty as Teresa (voice)

Wil Wheaton as Martin (voice)

Jodi Hicks as Cynthia (voice)

Ina Fried as Timothy (voice)

John Carradine as Great Owl (voice)

Peter Strauss as Justin (voice)

Paul Shenar as Jenner (voice)

Tom Hatten as Farmer Fitzgibbons (voice)

Lucille Bliss as Mrs. Fitzgibbons (voice)

Aldo Ray as Sullivan (voice)

Norbert Auerbach as Councilman 1 (voice)

Dick Kleiner as Councilman 2 (voice)

Charles Champlin as Councilman 3 (voice)

Joshua Lawrence as Billy Fitzgibbons (voice)

Philo Barnhart as Additional voices (uncredited)