Morgan Freeman as Theodore Joadson

Nigel Hawthorne as Martin Van Buren

Anthony Hopkins as John Quincy Adams

Djimon Hounsou as Cinque

Matthew McConaughey as Roger Sherman Baldwin

David Paymer as Secretary John Forsyth

Pete Postlethwaite as Holabird

Stellan Skarsgård as Tappan

Razaaq Adoti as Yamba

Abu Bakaar Fofanah as Fala

Anna Paquin as Queen Isabella

Tomas Milian as Calderon

Chiwetel Ejiofor as Ensign Covey

Derrick N. Ashong as Buakei

Geno Silva as Ruiz

John Ortiz as Montes

Ralph Brown as Lieutenant Gedney

Darren E. Burrows as Lieutenant Meade

Allan Rich as Judge Juttson

Paul Guilfoyle as Attorney

Peter Firth as Captain Fitzgerald

Xander Berkeley as Hammond

Jeremy Northam as Judge Coglin

Arliss Howard as John C. Calhoun

Willie Amakye as Folowa - Amistad African

Luc Assogba as Gbatui - Amistad African

Mariah Campbell as Masery - Amistad African

Habib Conteh as Bai - Amistad African

Stephen Conteh as Morlai - Amistad African

Monguehy Fanzy as Fabanna - Amistad African

Jimmy Fotso as Kwong - Amistad African

Adekunle Ilori as Kahei - Amistad African

Sheriff Kargbo as Almamy - Amistad African

Saye Lah as Kessebe - Amistad African

Sylvestre Massaquoi as Santigiie - Amistad African

Samson Odede as Kpona - Amistad African

Chike Okpala as Sorie - Amistad African

Willie Onafesso as Jina - Amistad African

Samuel Pieh as Suuleh - Amistad African

Lansana Sawi as Morlu - Amistad African

Abu Sidique as Tsukama - Amistad African

El Hadj Malik Sow as Golabu - Amistad African

Lamine Thiam as Mahmud - Amistad African

Austin Pendleton as Professor Gibbs

Daniel von Bargen as Warden Pendleton

Rusty Schwimmer as Mrs. Pendleton

Pedro Armendáriz Jr. as General Espatero

Frank T. Wells as Crier

Michael Massee as Prison Guard

Roy Cooper as Pickney

Jake Weber as Mr. Wright

Victor Rivers as Captain Ferrar

Joseph Kosseh as Birmaja

Steve Passewe as Cinque's In-Law

Sherly Acosta Williams as Cinque's Wife

Matt Sarles as Young Aide

George Gerdes as Marshal

Gerald R. Molen as Magistrate

Kevin J. O'Connor as Missionary

Robert E. Walsh as Guardsman

Sean McGuirk as Courier

Tony Owen as Farmer

William Young as Businessman

Michael Riley as British Officer

León Singer as Don Pablo

Castulo Guerra as Spanish Priest

Harry Groener as Tecora Captain

Hawthorne James as Creole Cook

Ingrid Walters as Woman Overboard with Baby

Harry A. Blackmun as Associate Justice Joseph Story

Curtis Shields as Bassie - Additional Amistad African

Carlos Spivey as Chike - Additional Amistad African

Charles Udoma as Kessebe - Additional Amistad African

Andrew L. Josiah as Tamba - Additional Amistad African

Tony Onafesso as Baa - Additional Amistad African

Peter Mansaray as Kapr - Additional Amistad African

Clarence Mobley as Kenei - Additional Amistad African

Brian Macon as Yauai - Additional Amistad African

Edward Appiah as Followolo - Additional Amistad African

Denver Dowridge as Kpau - Additional Amistad African

Paul Mwakutuya as Sessi - Additional Amistad African

Rory Burton as Vakina - Additional Amistad African

Samuel Orekhio as Fawni - Additional Amistad African

Omo Lara Tosin as Kula - Additional Amistad African

Ransford Thomas as Alkali - Additional Amistad African

Juliette Darko as Teme - Additional Amistad African

Charlean Isata Bangalie as Margru - Additional Amistad African

Roosevelt Flenoury as Njaooni - Additional Amistad African

M.S. Kaleiwo as Kaleiwo - Additional Amistad African

Tesfay Yohannes as Amistad African Extra

George Kamara as Amistad African Extra

Abdul-Fatai Balogun as Amistad African Extra

Yaya Sissoko as Amistad African Extra

Amadou Traore as Amistad African Extra

Marlon Francis as Amistad African Extra

Bundu Kamara as Amistad African Extra

James Moses as Amistad African Extra

Daniel Reid as Amistad African Extra

Seydou Coulibaly as Amistad African Extra

Lawal Tajudeen as Amistad African Extra

Lester Mombelly as Amistad African Extra

Ibrahim Sesay as Amistad African Extra

Jeremy Shelton as Amistad African Extra

Andrew Shoemo as Amistad African Extra

Prince Coke as Amistad African Extra

Ahmed Bangura as Amistad African Extra

Bernard Singleton as Amistad African Extra

Desere Mondon as Amistad African Extra

Baboucar Jobe as Amistad African Extra

Christopher Annino as Blacksmith (uncredited)

Susan Bergeron as Tyler Speech Attendee (uncredited)

Eric Bruno Borgman as First Jury Juror (uncredited)

Luis Cabrera as Spanish Guard (uncredited)

Craig Calman as Abolitionist (uncredited)

KimStacy Carter as Tecora Slave (uncredited)

Lisa Cavanaugh as Prostitute (uncredited)

Leonard Clifton as Slave (uncredited)

Alex Daunis as Clerk of Supreme Court (uncredited)

Nino Del Padre as Court Witness (uncredited)

Johnny Egan as Judge Coglin (voice) (uncredited)

Chris Fagan as Villager (uncredited)

Lawrence Gaughan as Spaniard (uncredited)

Morgan Hobart as Courtroom Spectator (uncredited)

Nick King as Villager (uncredited)

Luis Muñoz as Spanish Slave Guard (uncredited)

Ungenita Prevost as Tecora Slave (uncredited)

Glendon Rich as Slave / Abolishionist (uncredited)

Kevin M. Simon as Abolishionist (uncredited)

John H. Tobin as Supreme Court Reporter (uncredited)

Harrison Young as Congressman (uncredited)

Al Conti as Defense Attorney (uncredited)