Anthony Hopkins as Dr. John Harvey Kellogg

Bridget Fonda as Eleanor Lightbody

Matthew Broderick as William Lightbody

John Cusack as Charles Ossining

Dana Carvey as George Kellogg

Michael Lerner as Goodloe Bender

Colm Meaney as Dr. Lionel Badger

John Neville as Endymion Hart-Jones

Lara Flynn Boyle as Ida Muntz

Traci Lind as Nurse Irene Graves

Camryn Manheim as Virginia Cranehill

Roy Brocksmith as Poultney Dab

Norbert Weisser as Dr. Spitzvogel

Monica Parker as Mrs. Tindermarsh

Jacob Reynolds as Young George Kellogg

Michael Goodwin as Dr. Frank Linniman

Marshall Efron as Bartholomew Bookbinder

Aleksandr Slanksnis as Mr. Unpronounceable

Carole Shelley as Mrs. Hookstratten

Gabriel Barre as Desk Clerk

Robert Tracey as Ernest O'Reilly

Ann Tucker as Hannah

Jemila Ericson as Mrs. Kellogg

Marianne Muellerleile as Nurse Bloethal

Jean Wenderlich as Ralph

Mark Jeffrey Miller as Woodbine

Joanne Pankow as Laughing Lady

Mary Jane Corry as Pianist

Rich Valliere as Reporter #1

George Nannarello as Reporter #2

James Bigwood as Reporter #3

David Kraus as Laughing Instructor

D. Anthony Pender as Waiter on Train

Mary Lucy Bivins as Woman on Train

William Hempel as Bellman

Richard H. Thornton as Mr. Abernathy

Lisa Altomare as Mrs. Portois

Jim Bath as Bartender

Madeline Shaw as Waitress #1

Barbara Phillips as Waitress #2

Lindsay Hutchinson Berte as Breathing Instructor

Denise S. Bass as Nurse

Charlotte H. Ballinger as San Guest

John Henry Scott as Bath Attendant

Richard K. Olsen as Fox Fur Man

Ann Deagon as Fox Fur Woman

Thomas Myers Jr. as Process Server

Beth Bostic as Miss Jarvis

Kerry Maher as Doorman

Sam Garner as Farrington