Naomi Watts as Iris

Bill Murray as Walter

Ann Dowd as Marjorie

Constance Wu as Tuesday

Sarah Pidgeon as Val

Carla Gugino as Elaine

Noma Dumezweni as Barbara

Felix Solis as Hektor

Owen Teague as Carter

Bing as Apollo

Gina Costigan as Jocelyn

Josh Pais as Jerry

Cloé Xhauflaire as Camille

Susan Wands as Female Dinner Guest

Susan Lynskey as Host

Joel Van Liew as Male Dinner Guest

Annie Fox as Jenna

Carrie Vu as Viv

Sue Jean Kim as Blossom

Joe Castle Baker as Young Professor

Gary Littman as Grant

Sarah Baskin as Mara

Jess Gabor as Stella

Anna Fikhman as Nosy Neighbor

Bruce Norris as Dr. Novak

Amy Warren as Pantsuit Woman

Gabe Castillo as Security Guard

Juliet Brett as Sophie

Afsheen Misaghi as Shervin

Seth Barrish as Harry

Ian Lithgow as Larry

Jonathan Raviv as Party Goer

Matt Leisy as Dog Owner

Myrna Cabello as Lydia

Tom McCarthy as Dr. Warren

Gregory Abbey as Robert

John Leone as Conductor

Cedric Cannon as Chess Player (uncredited)

Grayson Powell as Bearded Writer (uncredited)

Alex Ziwak as New YOrk Rangers Fan (uncredited)