Gary Cooper as Marco Polo

Sigrid Gurie as Princess Kukachin

Basil Rathbone as Ahmed

George Barbier as Kublai Khan

Binnie Barnes as Nazama

Ernest Truex as Binguccio

Alan Hale as Kaidu

H.B. Warner as Chen Tsu

Robert Greig as Chamberlain

Ferdinand Gottschalk as Persian Ambassador

Henry Kolker as Nicolo Polo

Lotus Liu as Visakha

Stanley Fields as Bayan

Harold Huber as Toctai

Lana Turner as Maid

Ward Bond as Mongol Guard (uncredited)

Richard Farnsworth as Mongol Warrior (uncredited)

Hale Hamilton as Maffeo Polo (uncredited)

Theodore von Eltz as Venetian Business Man (uncredited)