André Holland as Tarrell

Andra Day as Aisha

John Earl Jelks as La'Ron

Aunjanue Ellis-Taylor as Joyce

Daniel Michael Barriere as Jermaine

Ian Foreman as Young Tarrell

Matthew Elam as Quentin

Jaime Ray Newman as Janine

G.L. McQueary as Michael

Tia Dionne Hodge as Regina

Justin Hofstad as Tommy

Daniel Allen Myers as Young Black Man

Dan Nainan as Dr. Parvez

Peter Van Wagner as Gus

Chip Carriere as Chaplain George

Tony Torn as Arthur

Cindy Jackson as Miss Hall

Caroline Keating as Flashback Nurse

Martha Morgan as Nurse 1

Jewel Turner as Nurse 2

Eric Newland as Dump Attendant

Alyssah Janey as Art Patron

Brawley Chisholm as Basketball Player (uncredited)

Natasja Naarendorp as Art Patron (uncredited)