Christopher Reeve as Dr. Alan Chaffee

Kirstie Alley as Dr. Susan Verner

Linda Kozlowski as Jill McGowan

Michael Paré as Frank McGowan

Meredith Salenger as Melanie Roberts

Mark Hamill as Reverend George

Pippa Pearthree as Sarah, George's Wife

Peter Jason as Ben Blum

Constance Forslund as Callie Blum

Karen Kahn as Barbara Chaffee

Thomas Dekker as David McGowan

Lindsey Haun as Mara Chaffee

Cody Dorkin as Robert

Trishalee Hardy as Julie

Jessye Quarry as Dorothy

Adam Robbins as Issac

Chelsea DeRidder Simms as Matt

Renee Rene Simms as Casey

Danielle Keaton as Lily

George Buck Flower as Carlton

Tony Haney as Dr. Bush

Ralph Miller as Village

John Carpenter as Man at Gas Station Phone

Seth Meyers as Trooper (uncredited)