Keanu Reeves as Eddie Kasalivich

Morgan Freeman as Paul Shannon

Rachel Weisz as Dr. Lily Sinclair

Fred Ward as FBI Agent Leon Ford

Kevin Dunn as FBI Agent Doyle

Brian Cox as Lyman Earl Collier

Joanna Cassidy as Maggie McDermott

Chelcie Ross as Ed Rafferty

Nicholas Rudall as Dr. Alistair Barkley

Tzi Ma as Lu Chen

Krzysztof Pieczyński as Lucasz Screbneski

Julie Pearl as Emily Pearl

Godfrey as Chidi Egbuna

Gene Barge as James Washington

Nathan Davis as Morris Grodsky

Aaron Williams as Lab Techie #3

Daniel H. Friedman as Video Dan

Johnny Lee Davenport as Caleb Williams

James Sie as Ken Lim

Joan Kohn as Sarah Fine

Juan Ramírez as Raymond Peña

Nydia Rodriguez Terracina as Gabrielle Guerrera

Scott Benjaminson as Stuart Showcroft

Ned Schmidtke as Wisconsin Chief Schmidke

Randall Arney as DC Technician

Noelle Bou-Sliman as DC Technician

Joseph F. Kosala as Sergeant Joe Byczkowski

Ron Dean as Sergeant Nick Zingaro

Miguel Nino as Officer Miguel

Turk Muller as Dane County Cop

Neil Flynn as State Trooper Nemitz

Michael Skewes as State Trooper Schwartz

Margaret Travolta as Anita Fermi

Jacqueline G. Arthur as Jackie Mann

Tom Mula as Chicago Administrator

Denise Price as Receptionist

Rick LeFevour as Matthew Haig

Charley Sherman as Justin Tidy

Gina Raffin as Colleen Dryden

Pam Zekman as Rita Bliss

Lisa Tejero as Dolores Enrique

David Pasquesi as Al Vanzetti

John Drummond as Drummond

Cathy Herd as TV Reporter

Tell Draper as TV Reporter

Danny Goldring as Clancy Butler

Eddie Bo Smith Jr. as Yusef Reed

Michael Gaylord James as Jim Gaylord

Ken Moreno as Naldo Partida

Allen Hamilton as Senator Phil Schmidt

Dick Cusack as Senate Chairman

Nicholas Kusenko as Staff Member Stennis

David Michael Gee as Senate Guard

Stanley M. Span as Firechief #1

Ann Whitney as Barkley's Lawyer

Rich Komenich as Bar Patron

Afram Bill Williams as Bridge Controller

Will Zahrn as Bridge Controller

John W. Hardy as Train Porter

Mary Seibel as Older Woman on Train

Nina Beesley as Flower Shop Owner

Michael Shannon as D.C. Flower Delivery Man

Billy Haynes as Doorman

Walter Doggett as Gate Guard

Jack Kandel as Panhandler

Timothy J. Maxwell as Homeless Husband

Leslie Mikol as Homeless Wife

Rio Zavala as Homeless Man

Mark Morettini as Romano

Soseh Kevorkian as Evelyn

Christopher Holloway as Max Holloway

Jim Ortlieb as Orbit

Cheryl Hamada as Hamada

Mike Gray as Swizlard

Joe Guastaferro as Tunnel Foreman