Leticia Dolera as Mary Morstan

Macarena Gómez as Bernabea

Manuela Velasco as Elena

Víctor Clavijo as Josito Alcántara

Enrique Villén as Enrique Valcárcel

Gary Piquer as Sherlock Holmes

José Luis García Pérez as Dr. Watson

Belén López as Irene Adler

Andrea Tenuta as Ángela

Juan Calot as Abberline

Jorge Roelas as Luis Delgado

Carlos Hipólito as Benito Pérez Galdós

Carlos Iglesias as Revisor

José Corbacho as Policía

Inocencio Arias as Ministro de fomento